EdenteV2, Main, Exploration, bibRecord, 003684

The Association of Serum Neutrophil Markers and Acute Coronary Syndrome

Identifieur interne : 003684 ( Main/Exploration ); précédent : 003683; suivant : 003685

The Association of Serum Neutrophil Markers and Acute Coronary Syndrome

Auteurs : Hatem Alfakry [Finlande] ; Juha Sinisalo [Finlande] ; Susanna Paju [Finlande] ; Markku S. Nieminen [Finlande] ; Ville Valtonen [Finlande] ; Taina Tervahartiala [Finlande] ; Pirkko J. Pussinen [Finlande] ; Timo Sorsa [Finlande]

Source :

Scandinavian Journal of Immunology [ 0300-9475 ] ; 2012-08.

RBID : ISTEX:874063A2071B92C09D9B599C2B3F50C9AC577A91

Descripteurs français

Wicri :
- topic : Maladie cardio-vasculaire, Immunologie.

English descriptors

Abstract

An association exists between chronic infection‐induced inflammation, such as periodontitis, and acute coronary syndrome (ACS). We studied the association of serum neutrophil markers, myeloperoxidase (MPO), matrix metalloproteinase (MMP)‐8, tissue inhibitor of metalloproteinase (TIMP)‐1 concentrations and MMP‐8/TIMP‐1 ratio, with the risk of recurrent ACS. Radiographic periodontal status was recorded from 141 patients with acute non‐Q‐wave infarction or unstable angina pectoris, who participated in a double‐blind, placebo‐controlled study with clarithromycin for 3 months. Serum samples were collected within arrival to the hospital, at 1 week, 3 months and 1 year. Recurrent ACS events were registered during the 1‐year follow‐up. In the whole population, high serum MPO concentrations at 1 week (fourth quartile versus quartiles 1–3) were associated with the risk of recurrent ACS with a relative risk (RR) of 2.52 (95% CI, 1.277–4.980; P = 0.008). In patients without periodontal disease, high MPO concentration at 1 week and 1 year predicted recurrent ACS with RRs of 3.54 (1.600–7.831; P = 0.002) and 2.87 (1.171–7.038; P = 0.021), respectively. In the placebo group, but not in the clarithromycin group, high serum MMP‐8/TIMP‐1 ratio at 1 week predicted recurrent ACS with an RR of 3.23 (1.295–8.063; P = 0.012). Our results suggest that high serum neutrophil markers reflect increased risk of recurrent ACS, especially in patients without periodontal disease and not receiving antimicrobial medication.

Url:

https://api.istex.fr/document/874063A2071B92C09D9B599C2B3F50C9AC577A91/fulltext/pdf

DOI: 10.1111/j.1365-3083.2012.02718.x

Affiliations:

Finlande

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute infarction</term>
<term>Alfakry</term>
<term>Antimicrobial medication</term>
<term>Arterioscler thromb vasc biol</term>
<term>Atherosclerosis</term>
<term>Atherosclerotic lesions</term>
<term>Baseline</term>
<term>Biol chem</term>
<term>Blackwell publishing</term>
<term>Bras cardiol</term>
<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Chronic periodontitis</term>
<term>Clarithromycin</term>
<term>Clarithromycin group</term>
<term>Clin chem</term>
<term>Coronary artery disease</term>
<term>Dental status</term>
<term>Endothelial cells</term>
<term>Epidemiologic studies</term>
<term>Fourth quartile</term>
<term>Hatem alfakry</term>
<term>Helsinki</term>
<term>Helsinki university</term>
<term>High serum</term>
<term>High serum ratio</term>
<term>Immunology</term>
<term>Major molecule</term>
<term>Marker</term>
<term>Matrix</term>
<term>Matrix metalloproteinases</term>
<term>Metalloproteinases</term>
<term>Mmps</term>
<term>Myeloperoxidase</term>
<term>Myocardial infarction</term>
<term>Neutrophil</term>
<term>Nonperiodontitis patients</term>
<term>Periodontal</term>
<term>Periodontal breakdown</term>
<term>Periodontal disease</term>
<term>Periodontal infection</term>
<term>Periodontal pathogens</term>
<term>Periodontitis</term>
<term>Periodontitis patients</term>
<term>Placebo</term>
<term>Placebo group</term>
<term>Plaque rupture</term>
<term>Population placebo</term>
<term>Porphyromonas gingivalis</term>
<term>Present study</term>
<term>Previous studies</term>
<term>Protective factor</term>
<term>Pussinen</term>
<term>Ranks test</term>
<term>Recurrent</term>
<term>Regression analysis</term>
<term>Regression model</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Sampling points</term>
<term>Scandinavian journal</term>
<term>Serum neutrophil markers</term>
<term>Serum samples</term>
<term>Sorsa</term>
<term>Subgroup</term>
<term>Taina tervahartiala</term>
<term>Timo sorsa</term>
<term>Tissue destruction</term>
<term>Tissue inhibitor</term>
<term>Tissue inhibitors</term>
<term>Unstable angina pectoris</term>
<term>Value4</term>
<term>Value4 placebo clarithromycin</term>
<term>Whole group</term>
<term>Whole population</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acute infarction</term>
<term>Alfakry</term>
<term>Antimicrobial medication</term>
<term>Arterioscler thromb vasc biol</term>
<term>Atherosclerosis</term>
<term>Atherosclerotic lesions</term>
<term>Baseline</term>
<term>Biol chem</term>
<term>Blackwell publishing</term>
<term>Bras cardiol</term>
<term>Cardiovascular</term>
<term>Cardiovascular disease</term>
<term>Chronic periodontitis</term>
<term>Clarithromycin</term>
<term>Clarithromycin group</term>
<term>Clin chem</term>
<term>Coronary artery disease</term>
<term>Dental status</term>
<term>Endothelial cells</term>
<term>Epidemiologic studies</term>
<term>Fourth quartile</term>
<term>Hatem alfakry</term>
<term>Helsinki</term>
<term>Helsinki university</term>
<term>High serum</term>
<term>High serum ratio</term>
<term>Immunology</term>
<term>Major molecule</term>
<term>Marker</term>
<term>Matrix</term>
<term>Matrix metalloproteinases</term>
<term>Metalloproteinases</term>
<term>Mmps</term>
<term>Myeloperoxidase</term>
<term>Myocardial infarction</term>
<term>Neutrophil</term>
<term>Nonperiodontitis patients</term>
<term>Periodontal</term>
<term>Periodontal breakdown</term>
<term>Periodontal disease</term>
<term>Periodontal infection</term>
<term>Periodontal pathogens</term>
<term>Periodontitis</term>
<term>Periodontitis patients</term>
<term>Placebo</term>
<term>Placebo group</term>
<term>Plaque rupture</term>
<term>Population placebo</term>
<term>Porphyromonas gingivalis</term>
<term>Present study</term>
<term>Previous studies</term>
<term>Protective factor</term>
<term>Pussinen</term>
<term>Ranks test</term>
<term>Recurrent</term>
<term>Regression analysis</term>
<term>Regression model</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Sampling points</term>
<term>Scandinavian journal</term>
<term>Serum neutrophil markers</term>
<term>Serum samples</term>
<term>Sorsa</term>
<term>Subgroup</term>
<term>Taina tervahartiala</term>
<term>Timo sorsa</term>
<term>Tissue destruction</term>
<term>Tissue inhibitor</term>
<term>Tissue inhibitors</term>
<term>Unstable angina pectoris</term>
<term>Value4</term>
<term>Value4 placebo clarithromycin</term>
<term>Whole group</term>
<term>Whole population</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term>
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<front><div type="abstract" xml:lang="en">An association exists between chronic infection‐induced inflammation, such as periodontitis, and acute coronary syndrome (ACS). We studied the association of serum neutrophil markers, myeloperoxidase (MPO), matrix metalloproteinase (MMP)‐8, tissue inhibitor of metalloproteinase (TIMP)‐1 concentrations and MMP‐8/TIMP‐1 ratio, with the risk of recurrent ACS. Radiographic periodontal status was recorded from 141 patients with acute non‐Q‐wave infarction or unstable angina pectoris, who participated in a double‐blind, placebo‐controlled study with clarithromycin for 3 months. Serum samples were collected within arrival to the hospital, at 1 week, 3 months and 1 year. Recurrent ACS events were registered during the 1‐year follow‐up. In the whole population, high serum MPO concentrations at 1 week (fourth quartile versus quartiles 1–3) were associated with the risk of recurrent ACS with a relative risk (RR) of 2.52 (95% CI, 1.277–4.980; P = 0.008). In patients without periodontal disease, high MPO concentration at 1 week and 1 year predicted recurrent ACS with RRs of 3.54 (1.600–7.831; P = 0.002) and 2.87 (1.171–7.038; P = 0.021), respectively. In the placebo group, but not in the clarithromycin group, high serum MMP‐8/TIMP‐1 ratio at 1 week predicted recurrent ACS with an RR of 3.23 (1.295–8.063; P = 0.012). Our results suggest that high serum neutrophil markers reflect increased risk of recurrent ACS, especially in patients without periodontal disease and not receiving antimicrobial medication.</div>
</front>
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<affiliations><list><country><li>Finlande</li>
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<name sortKey="Nieminen, Markku S" sort="Nieminen, Markku S" uniqKey="Nieminen M" first="Markku S." last="Nieminen">Markku S. Nieminen</name>
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<name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name>
<name sortKey="Sinisalo, Juha" sort="Sinisalo, Juha" uniqKey="Sinisalo J" first="Juha" last="Sinisalo">Juha Sinisalo</name>
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The Association of Serum Neutrophil Markers and Acute Coronary Syndrome

The Association of Serum Neutrophil Markers and Acute Coronary Syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri